Some aspects of post-infectious anti-cholera immunity formation

Ivanova I.A., Zhukovа O.G., Omelchenko N.D., Filippenko A.V., Trufanova A.A.

Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Rostov-on-Don, Russia

The purpose of the review is to analyze publications on the formation of post-infectious anti-cholera immunity. The review analyzes scientific articles published in recent decades by Russian and foreign scientists in scientific journals listed in the PubMed, Web of Science, Google Scholar, Scopus, and RSCI databases, which focused on deciphering the mechanisms of immune response in individuals who have recovered from cholera. The review summarizes information about the main antigens of Vibrio cholerae that cause immunological changes in patients with cholera, as well as data on some stages of activation of innate immunity and the formation of cellular and humoral post-infection anti-cholera immune responses. The results of the literature analysis indicate the need for further research of individual populations of regulatory and effector cells at different stages of anti-cholera immunity development, including immunological memory, as well as identifying factors that contribute to its longer preservation in individuals who have recovered from the disease.